Perspectives in diabetes.

نویسنده

  • W L HENRY
چکیده

D-glucose induces a rise in pancreatic islet p-cell component of the p-cell fuel sensor apparatus; and 5) cytosolic [C~Z+] by processes requiring both glucose arachidonate 12-LO metabolites are potential metabolism and Ca2+ entry from the extracellular candidates as adjunctive modulators of p-cell space, and this Ca2+ signal is thought to be critical to K+-channel activity. Diabetes 42:367-74, 1993 the induction of insulin secretion. Insulin secretagogues also induce phospholipid hydrolysis and accumulation of phospholipib-derived-medhtors in islets, including the lipid messengers DAG, nonesterified arachidonic acid, and arachidonate 12-LO products. This study offers the following viewpoints on potential roles of these lipid messengers in insulin secretion as working hypotheses: 1) the Ca2+ signal provided to the @cell by D-glucose induces insulin secretion only in the context of amplifying background signals provided by the p-cell content of messengers including DAG; 2) muscarinic receptor agonists amplify glucose-induced insulin secretion in part by altering the p-cell content of DAG; 3) the Ca2+ signal provided by metabolism of D-glucose is amplified by the level of nonesterified arachidonic acid in p-cell membranes, which acts to facilitate Ca2+ entry; 4) metabolism of glucose induces accumulation of nonesterified arachidonate in p-cells via activation of a recently identified ASCI-PLA, enzyme, which may be a

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Diabetes in India: Perspectives on Awareness and Care

Background and aims: Diabetes is a major killing recognized as a silent epidemic globally problem. India has the highest number of diabetes cases in the world causing huge morbidity and economic losses to the country. There were 66.8 million adults suffering from with diabetes in India in 2014, which is expected to rise by 63% to 109 million by 2035. Diabetes led to at least US...

متن کامل

New Perspectives on the Role of Hyperglycemia, Free Fatty Acid and Oxidative Stress in B-Cell Apoptosis

Apoptosis is a complex network of biochemical and molecular pathway with fine regulatory mechanisms that control the death event during several pathological situations in multi cellular organisms. It is the part of normal development that occurs in a variety of diseases and is known as aberrant apoptosis. Pancreatic β cell apoptosis is also a pathological feature which is common in both type 1 ...

متن کامل

Bringing Value-Based Perspectives to Care: Including Patient and Family Members in Decision-Making Processes

Background Recent evidence shows that patient engagement is an important strategy in achieving a high performing healthcare system. While there is considerable evidence of implementation initiatives in direct care context, there is limited investigation of implementation initiatives in decision-making context as it relates to program planning, service delivery and developing policies. Research ...

متن کامل

The role of environmental factors in insulin-dependent diabetes mellitus: an unresolved issue.

Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease characterized by the destruction of the insulin-secreting beta cells found in the islets of Langerhans. Reduced beta-cell mass results in overt diabetes, requiring lifelong exogenous insulin administration and the possibility of numerous sequelae. Incidence and development of IDDM depend upon a variety of genetic and nongenetic...

متن کامل

Cultural perspectives of interventions for managing diabetes and asthma in children and adolescents from ethnic minority groupscch_1101

Rights © 2010 Blackwell Publishing Ltd. This is the pre-peer reviewed version of the following article: MC MANUS, V. & SAVAGE, E. 2010. Cultural perspectives of interventions for managing diabetes and asthma in children and adolescents from ethnic minority groups. Child: Care, Health and Development, 36, 612-622, which has been published in final form at http://dx.doi.org/10.1111/j.13652214.201...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of the National Medical Association

دوره 54  شماره 

صفحات  -

تاریخ انتشار 1962